Publications
Recommended Publications
Harnessing Genetic Complexity to Enhance Translatability of Alzheimer's Disease Mouse Models: A Path toward Precision Medicine
Neuner, S. M., Heuer, S. E., Huentelman, M. J., O'Connell, K. M. S., & Kaczorowski, C. C. (2019). Harnessing Genetic Complexity to Enhance Translatability of Alzheimer's Disease Mouse Models: A Path toward Precision Medicine. Neuron, 101(3), 399–411.e5. https://doi.org/10.1016/j.neuron.2018.11.040
In the news:
Animal models of Alzheimer’s disease embrace diversity
Alzheimer’s disease remains untreatable, despite decades of preclinical research to understand it better and find therapeutic targets. New ways of thinking about a variety animal models are rising to the challenge.
Nature, LabAnimal, Animal models of Alzheimer’s disease embrace diversity 08/19/2019
In the news:
Effects of Species-Specific Genetics on Alzheimer’s Mouse Models
In this issue of Neuron, Neuner et al. (2019) report the generation of Alzheimer’s disease (AD) transgenic mouse models on a panel of 28 background strains, showing marked background-dependent phenotypic variability. These findings imply that analogous variation in human AD phenotypes may be due, at least in part, to subtle effects of genetic background.
Neuron Previews, Effects of Species-Specific Genetics on Alzheimer’s Mouse Models 02/06/2019
In the news:
Improved Alzheimer’s Mouse Model Paves the Way to Precision Medicine
“This is the first study to show that you can replicate many of the molecular features of Alzheimer’s disease in a genetically diverse mouse model,” says NIA director Richard J. Hodes, M.D. “It points to a strategy for better use of mouse models for precision medicine research—both basic and translational—for Alzheimer’s disease.”
Genetic Engineering & Biotechnology News “Improved Alzheimer’s Mouse Model Paves the Way to Precision Medicine “ 12/27/2018
Translational approaches to understanding resilience to Alzheimer's disease
Neuner, S. M., Telpoukhovskaia, M., Menon, V., O'Connell, K. M. S., Hohman, T. J., & Kaczorowski, C. C. (2022). Translational approaches to understanding resilience to Alzheimer's disease. Trends in neurosciences, 45(5), 369–383. https://doi.org/10.1016/j.tins.2022.02.005
In the news:
A better mouse: Using genetic diversity to accelerate Alzheimer’s research
“Alzheimer’s is an extremely complex disease, and one contributor to clinical trial failures may be that we aren’t testing drug candidates on models that accurately reflect the disease,” says Dr. Diane Bovenkamp, Vice President of Scientific Affairs at BrightFocus Foundation. “Dr. Kaczorowski, and her colleagues are the first to produce mice that have genetic diversity similar to that present in the human population, which will enable her and other researchers to discover what is modifying the age of onset or increasing the risk of memory failure.”
Journal Tribune A better mouse: Using genetic diversity to accelerate Alzheimer’s research 12/29/2018
Identifying the molecular systems that influence cognitive resilience to Alzheimer's disease in genetically diverse mice
Heuer, S. E., Neuner, S. M., Hadad, N., O'Connell, K. M. S., Williams, R. W., Philip, V. M., Gaiteri, C., & Kaczorowski, C. C. (2020). Identifying the molecular systems that influence cognitive resilience to Alzheimer's disease in genetically diverse mice. Learning & memory (Cold Spring Harbor, N.Y.), 27(9), 355–371. https://doi.org/10.1101/lm.051839.120
Gene-by-environment interactions in Alzheimer’s disease and Parkinson’s disease
Dunn, A. R., O'Connell, K. M. S., & Kaczorowski, C. C. (2019). Gene-by-environment interactions in Alzheimer's disease and Parkinson's disease. Neuroscience and biobehavioral reviews, 103, 73–80. https://doi.org/10.1016/j.neubiorev.2019.06.018
Life-long dietary restrictions have negligible or damaging effects on late-life cognitive performance: A key role for genetics in outcomes
Ouellette, A. R., Hadad, N., Deighan, A., Robinson, L., O'Connell, K., Freund, A., Churchill, G. A., & Kaczorowski, C. C. (2022). Life-long dietary restrictions have negligible or damaging effects on late-life cognitive performance: A key role for genetics in outcomes. Neurobiology of aging, 118, 108–116. https://doi.org/10.1016/j.neurobiolaging.2022.07.004
Detecting the effect of genetic diversity on brain composition in an Alzheimer's disease mouse model
Gurdon, B., Yates, S. C., Csucs, G., Groeneboom, N. E., Hadad, N., Telpoukhovskaia, M., Ouellette, A., Ouellette, T., O'Connell, K., Singh, S., Murdy, T., Merchant, E., Bjerke, I., Kleven, H., Schlegel, U., Leergaard, T. B., Puchades, M. A., Bjaalie, J. G., & Kaczorowski, C. C. (2023). Detecting the effect of genetic diversity on brain composition in an Alzheimer's disease mouse model. bioRxiv : the preprint server for biology, 2023.02.27.530226. https://doi.org/10.1101/2023.02.27.530226
Conserved cell-type specific signature of resilience to Alzheimer’s disease nominates role for excitatory cortical neurons
Telpoukhovskaia, M., Hadad, N., Gurdon, B., Dai, M., Ouellette, A.R., Neuner, S., Dunn, A.R., Hansen, S.L., Wu, Y., Dumitrescu, L., O'Connell, K.M., Dammer, E.B., Seyfried, N.T., Muzumdar, S., Gillis, J., Robson, P., Zhang, J., Hohman, T.J., Philip, V.M., Menon, V. and Kaczorowski, C.C. (2022), Conserved cell-type specific signature of resilience to Alzheimer’s disease nominates role for excitatory cortical neurons. Alzheimer's Dement., 18: e069370. https://doi.org/10.1002/alz.069370