Discover and download Alzheimer's Disease data, analyses, and tools from the National Institute on Aging's Alzheimer's Disease Translational Research Program.

Agora hosts high-dimensional human transcriptomic, proteomic, and metabolomic evidence for whether or not genes are associated with Alzheimer’s Disease (AD). Agora also contains a list of over 900 nascent AD drug targets that were nominated by researchers from the National Institute on Aging's AMP-AD consortium and TREAT-AD centers, as well as by other AD research teams.

GenomeMUSter is a comprehensive SNP data resource that includes typed, sequenced, and imputed genotypes of 657 inbred mouse strains and their derivatives across chromosomes 1-19, X, Y, and Mt. Genotypes from ten legacy datasets available from MPD, the Sanger REL2004 and REL1505, whole genome sequencing of the Collaborative Cross (CC), BXD recombinant inbred strains and C57BL/6J Eve (B6Eve), and long read whole genome sequencing of 42 inbred strains were merged by chromosome and within chromosome in 10 Mb segmented regions. 

The mammalian brain is composed of a vast (and unknown) number of specialized cell types whose complex interactions underlie behavior. To better appreciate these cellular specializations — and the genes that cells of diverse types use to perform their jobs — we used Drop-seq to analyze 690,000 individual cells from nine different regions of the adult mouse brain. We identified 1.45 billion RNA transcripts among these cells, then used the cells' patterns of RNA expression to classify them into transcriptionally distinct groups of cells (clusters and subclusters). Most of these clusters and subclusters correspond to discrete cell types; some to dynamic cell states; and many, we expect, to aspects of cell biology that remain to be discovered.

The Knockout Mouse Program (KOMP2) is an NIH initiative that, together with the other members of the International Knockout Mouse Consortium (IKMC), aims to generate a public resource comprised of knockout information for all protein-coding genes in the mouse genome.

Created by Sage Bionetworks, Synapse empowers biomedical researchers with tools for open science and collaboration.

Allen Institute for Brain Science has assessed gene expression in the brain of mouse, human, and non-human primate in developing, adult, and aged individuals. Such atlases represent a key step towards understanding the functional genomics of the nervous system and provide a transcriptional baseline for neurogenetic studies of normal and abnormal human brain function.

Single cell (or single nucleus) RNA sequencing (RNA-Seq) is a scalable approach to provide genome-wide expression profiles for thousands of cells. This data set includes single cell and nuclear transcriptomic profiles, assayed from human and mouse brain regions. Anatomical specificity is achieved by microdissecting tissue from defined brain areas, such as cortical layers or cell groups in LGd.

The Seattle Alzheimer’s Disease Brain Cell Atlas (SEA-AD) consortium strives to gain a deep molecular and cellular understanding of the early pathogenesis of Alzheimer’s disease. We provide free, open resources to the scientific community.

CHDI makes human biosamples available to the HD research community to facilitate a broad variety of HD research and accelerate progress towards the development of therapeutics. 

Easy access to validated biological reagents removes resource barriers for researchers currently working on Huntington’s disease (HD) and for others new to the field.